"On Water" Direct C-3 Arylation of 2H-Pyrazolo[3,4-b]pyridines.
Soukaina FaarasseSaïd El KazzouliMohammed NaasJabrane JouhaFranck SuzenetGérald GuillaumetPublished in: The Journal of organic chemistry (2017)
An "on water" palladium-catalyzed direct (hetero)arylation of 2H-pyrazolo[3,4-b]pyridines has been developed. The reactions proceeds smoothly with at low catalytic loading at low temperature providing the C3 (hetero)arylated products in good to excellent isolated yields. Free NH 3-arylated 7-azaindazoles were also prepared by simple cleavage of the N-protected groups.
Keyphrases