A transcriptomic study of probenecid on injured spinal cords in mice.
Yu-Xin ZhangSai-Nan WangJing ChenJian-Guo HuHe-Zuo LüPublished in: PeerJ (2020)
RNA-Seq showed that, compared to the SCI_C group, the number of DEGs was 641 in the SCI_P group (286 upregulated and 355 downregulated). According to GO analysis, DEGs were most enriched in extracellular matrix (ECM), collagen trimer, protein bounding and sequence specific DNA binding. KEGG analysis showed that the most enriched pathways included: cell adhesion molecules, Leukocyte transendothelial migration, ECM-receptor interactions, PI3K-Akt signaling pathways, hematopoietic cell lineages, focal adhesions, the Rap1 signaling pathway, etc. The sequence data have been deposited into the Sequence Read Archive (https://www.ncbi.nlm.nih.gov/sra/PRJNA554464).
Keyphrases
- signaling pathway
- pi k akt
- extracellular matrix
- rna seq
- single cell
- dna binding
- spinal cord injury
- cell adhesion
- cell proliferation
- epithelial mesenchymal transition
- cell cycle arrest
- amino acid
- induced apoptosis
- spinal cord
- type diabetes
- small molecule
- protein protein
- skeletal muscle
- oxidative stress
- machine learning
- insulin resistance
- endoplasmic reticulum stress