Early systemic insults following traumatic brain injury: association with biomarker profiles, therapy for intracranial hypertension, and neurological outcomes-an analysis of CENTER-TBI data.
Chiara RobbaFrancesca GrazianoEdoardo PicettiCecilia ÅkerlundAlberto AddisGiuseppe PastoreMattia SiveroPaola ReboraStefania GalimbertiNino StocchettiAndrew MaasDavid K MenonGuiseppe Citerionull nullPublished in: Intensive care medicine (2024)
Though less frequent than previously described, SIs in TBI patients are associated with higher release of neuronal than glial injury biomarkers and with increased requirements for ICU therapies aimed at reducing intracranial hypertension. Hypotension or combined SIs are significantly associated with adverse 6-month outcomes. Current criteria for hypotension may lead to higher biomarker levels and more negative outcomes than those for hypoxemia suggesting a need to revisit pressure targets in the prehospital settings.
Keyphrases
- traumatic brain injury
- blood pressure
- end stage renal disease
- newly diagnosed
- ejection fraction
- intensive care unit
- chronic kidney disease
- emergency department
- type diabetes
- insulin resistance
- spinal cord
- adipose tissue
- mechanical ventilation
- machine learning
- skeletal muscle
- cerebral ischemia
- trauma patients
- optical coherence tomography