Endothelial OCT4 is atheroprotective by preventing metabolic and phenotypic dysfunction.

Junchul ShinSvyatoslav TkachenkoMalay ChakladerConnor PletzKanwardeep SinghGamze B BulutYoung Min HanKelly MitchellRichard A BaylisAndrey A KuzminBo HuJustin D LathiaOlga Stenina-AdognraviEugene PodrezTatiana V ByzovaGary K OwensOlga A Cherepanova

Published in: Cardiovascular research (2022)

These results provide the first direct evidence that OCT4 has a protective metabolic function in EC and identifies vascular OCT4 and its signalling axis as a potential target for novel therapeutics.

Keyphrases

optical coherence tomography
diabetic retinopathy
optic nerve
endothelial cells
oxidative stress
small molecule
human health