Progressive Multiple Sclerosis Is Associated with Faster and Specific Retinal Layer Atrophy.
Elias S SotirchosNatalia Gonzalez CalditoAngeliki G FilippatouKathryn C FitzgeraldOlwen C MurphyJeffrey LambeJames NguyenJulia ButtonEsther OgbuokiriCiprian M CrainiceanuJerry L PrincePeter A CalabresiShiv Saidhanull nullPublished in: Annals of neurology (2020)
PMS is associated with faster retinal atrophy independent of age. INL and ONL measures may be novel biomarkers of neurodegeneration in PMS that appear to be unaffected by conventional DMTs. The effects of aging on rates of retinal layer atrophy should be considered in clinical trials incorporating OCT outcomes. ANN NEUROL 2020;87:885-896.