Mitochondrial genome-wide association study of migraine - the HUNT Study.
Sigrid BørteJohn-Anker ZwartAnne Heidi SkogholtMaiken Elvestad GabrielsenLaurent F ThomasLars G FritscheIda SurakkaJonas B NielsenWei ZhouBrooke N WolfordMagnus D VigelandKnut HagenEspen Saxhaug KristoffersenDale R NyholtDaniel I ChasmanBen M BrumptonCristen J WillerBendik S WinsvoldPublished in: Cephalalgia : an international journal of headache (2020)
Our findings do not support a major role of mitochondrial genetic variation in migraine pathophysiology, but a larger sample is needed to detect rare variants and future studies should also examine heteroplasmic variation, epigenetic changes and copy-number variation.