Epigenome-Wide Association Study Using Prediagnostic Bloods Identifies New Genomic Regions Associated With Pancreatic Cancer Risk.

Dominique S MichaudMengyuan RuanDevin C KoestlerDong PeiCarmen J MarsitImmaculata De VivoKarl T Kelsey

Published in: JNCI cancer spectrum (2020)

Changes in DNA methylation in peripheral blood may mark alterations in metabolic or immune pathways that play a role in pancreatic cancer. Identifying new biological pathways in carcinogenesis of pancreatic cancer using epigenome-wide association studies approach could provide new opportunities for improving treatment and prevention.

Keyphrases

dna methylation
genome wide
peripheral blood
gene expression
copy number
replacement therapy
smoking cessation