Thiophene assisted cellular uptake enhancement for highly efficient NIR-II cancer phototheranostics.

Yue ZhangJia YuChunbin LiJianye GongYifan WuLina FengZihan ChenRenmanduhu ShaGuoyu Jiang Jianguo Wang

Published in: Chemical communications (Cambridge, England) (2024)

We designed two series of NIR-II PTAs with D-A or D-A-D structures, in which the introduction of thiophene promotes a bathochromic shift of emission into the NIR-II region, helps to improve the cellular uptake of the PTAs and facilitates NIR-II imaging-guided PDT/PTT cancer phototherapy.

Keyphrases

photodynamic therapy
highly efficient
fluorescence imaging
papillary thyroid
drug release
fluorescent probe
high resolution
young adults
childhood cancer