Microparticles derived from human erythropoietin mRNA-transfected mesenchymal stem cells inhibit epithelial-to-mesenchymal transition and ameliorate renal interstitial fibrosis.

Mirae LeeSeok-Hyung KimJong Hyun JheeTae Yeon KimHoon Young ChoiHyung Jong KimHyeong Cheon Park

Published in: Stem cell research & therapy (2020)

Our results demonstrate that hEPO-MPs modulate TGF-β1-induced EMT in MDCK cells via the Smad2, Smad3, and p38 MAPK pathways and significantly attenuated renal TIF in UUO kidneys.

Keyphrases

transforming growth factor
epithelial mesenchymal transition
mesenchymal stem cells
induced apoptosis
endothelial cells
high glucose
cell cycle arrest
signaling pathway
umbilical cord
bone marrow
drug induced
cell death
cell therapy