Adaptive and Constitutive Activations of Malic Enzymes Confer Liver Cancer Multilayered Protection Against Reactive Oxygen Species.
Derek LeeMisty Shuo ZhangFelice Ho-Ching TsangMacus Hao-Ran BaoIris Ming-Jing XuRobin Kit-Ho LaiDavid Kung-Chun ChiuAki Pui-Wah TseCheuk-Ting LawCerise Yuen-Ki ChanVincent Wai-Hin YuenNoreen Nog-Qin ChuiIrene Oi Lin NgChun Ming WongCarmen Chak-Lui WongPublished in: Hepatology (Baltimore, Md.) (2022)
Our study reveals the complementary regulatory mechanisms which control MEs and provide cancer cells multiple layers of defense against oxidative stress. Targeting both regulatory mechanisms represents a potential therapeutic approach for HCC treatment.