SMYD2 induced PGC1α methylation promotes stemness maintenance of glioblastoma stem cells.
Mengdie LiZhixiang ZhangLiuguijie HeXiefeng WangJianxing YinXiuxing WangYongping YouXu QianXin GeZhumei ShiPublished in: Neuro-oncology (2024)
These findings unveil a novel regulatory pathway involving mitochondria that governs stemness in GSCs, thereby emphasizing promising therapeutic strategies targeting PGC1α and mitochondria for the treatment of GBM.