Quantitative proteomic analysis of bronchoalveolar lavage fluids from patients with small cell lung cancers.
Hung M VuHazara Begum MohammadThy N C NguyenJun Hyung LeeYeji DoJi-Youn SungSeung Hyeun LeeMin-Sik KimPublished in: Proteomics. Clinical applications (2023)
BALF is an emerging source of biomarkers, making it useful for the diagnosis and prognosis of lung cancers. We characterized the proteomes of paired BALF samples collected from tumor-bearing and non-tumor lungs of SCLC patients. Several proteins were found elevated in tumor-bearing BALF, and especially CNDP2 and RNPEP appeared to be potential indicators for ASLC1-high and NEUROD1-high subtypes of SCLC, respectively. The positive correlation of CNDP2 with chemo-drug responses would help to make decisions for treatment of SCLC patients. These putative biomarkers could be comprehensively investigated for a clinical use towards precision medicine. This article is protected by copyright. All rights reserved.