Is brain arousal regulation a predictor of response to psychostimulant therapy in adult ADHD patients?
Maria StraußAndreas ReifChristine UlkeMadlen PauckeChristian SanderUlrich HegerlHeike WeberJulia HeupelJuliane KopfKatharina LichterPublished in: European archives of psychiatry and clinical neuroscience (2019)
We investigated whether baseline brain arousal instability during resting state EEG, using the Vigilance Algorithm Leipzig (VIGALL 2.1), can predict response to methylphenidate therapy in adult ADHD patients. An arousal stability score of the EEGs of 28 adult ADHD patients was calculated quantifying the extent of arousal decline. In logistic regression analysis, arousal stability score predicted response to MPH [odds ratio 1.28 (95% CI 1.0-1.65); p = 0.027]. In this pilot study, we demonstrated that arousal stability at baseline predicted methylphenidate treatment response, indicating that less stable arousal regulation during a 15-min EEG at rest increases the chance of treatment response.
Keyphrases
- resting state
- attention deficit hyperactivity disorder
- functional connectivity
- end stage renal disease
- newly diagnosed
- working memory
- peritoneal dialysis
- autism spectrum disorder
- prognostic factors
- mesenchymal stem cells
- patient reported outcomes
- white matter
- young adults
- high resolution
- mass spectrometry
- cerebral ischemia
- replacement therapy