Genomic landscape and actionable mutations of brain metastases derived from non-small cell lung cancer: A systematic review.
Lily J AndrewsZak A ThorntonRuqiya SalehSarah DawsonSusan C ShortRichard DalyJulian P T HigginsPhilippa DaviesKathreena M KurianPublished in: Neuro-oncology advances (2023)
To our knowledge, this is the first systematic review to describe the genomic landscape of brain metastases derived from NSCLC. These results provide a comprehensive outline of frequently mutated genes and missense mutations that could be clinically actionable. These data also provide evidence of differing genomic landscapes between ever versus never smokers and primary NSCLC compared to the BM. This information could have important consequences for the selection and development of targeted drugs for these patients.
Keyphrases
- brain metastases
- small cell lung cancer
- systematic review
- copy number
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- healthcare
- meta analyses
- prognostic factors
- single cell
- genome wide
- patient reported outcomes
- cancer therapy
- health information
- gene expression
- advanced non small cell lung cancer
- deep learning
- bioinformatics analysis