Cell type-specific mechanisms coupling protease-activated receptor-1 to infectious colitis pathogenesis.

Alexander A BoucherLeah RosenfeldtDuaa MurebJessica ShaferBal Krishan SharmaAdam LaneRebecca R CrowtherMelanie C McKellJordan WhittTheresa AlenghatJoseph QuallsSilvio AntoniakNigel MackmanMatthew J FlickKris A SteinbrecherJoseph S Palumbo

Published in: Journal of thrombosis and haemostasis : JTH (2019)

These studies reveal complex, cell type-specific roles for PAR-1 in modulating the immune response to Citrobacter colitis that are not readily apparent in analyses limited to mice with global PAR-1 deficiency.

Keyphrases

ulcerative colitis
signaling pathway
single cell
magnetic resonance imaging
computed tomography
dna methylation
skeletal muscle
adipose tissue
diffusion weighted imaging
wild type
contrast enhanced