Diffuse Bone Marrow Metastasis as the Initial Presentation of an Occult Breast Cancer.
Frank Sheng FanChung-Fan YangYi-Fen WangPublished in: Case reports in oncological medicine (2018)
Mucin 1 (MUC1), also known as cancer antigen 15-3 (CA 15-3), facilitates motility and metastatic potential of breast cancer cells. Interleukin-1β (IL-1β) drives breast cancer cell growth and colonization in bone marrow adipose tissue niche. Receptor activator of nuclear factor kappa-B (RANK) and its ligand (RANKL) activate osteoclasts to make a favorable bone marrow microenvironment for tumor cells. Agents against MUC1, IL-1β, and RANKL might be of therapeutic effect for patients like ours.
Keyphrases
- nuclear factor
- bone marrow
- toll like receptor
- mesenchymal stem cells
- adipose tissue
- breast cancer cells
- newly diagnosed
- ejection fraction
- small cell lung cancer
- stem cells
- prognostic factors
- insulin resistance
- papillary thyroid
- inflammatory response
- immune response
- low grade
- escherichia coli
- bone loss
- squamous cell
- case report
- childhood cancer