Driver mutations occur frequently in metastases of well-differentiated small intestine neuroendocrine tumours.

Kris G SamsomSonja LevyLinde M van VeenendaalPaul RoepmanLiudmila L KodachNeeltje SteeghsGerlof D ValkM Wouter DercksenKoert F D KuhlmannWieke H M VerbeekGerrit A MeijerMargot E T TesselaarJosé G van den Berg

Published in: Histopathology (2020)

Driver mutations occur in 50% of metastasised SI-NETs, and their presence is associated with a high Ki67 proliferation index. The identification of targetable mutations make these patients potentially eligible for targeted therapy.

Keyphrases

ejection fraction
newly diagnosed
prognostic factors
signaling pathway
room temperature
patient reported
rectal cancer