Polygenic Risk and Chemotherapy-Related Subsequent Malignancies in Childhood Cancer Survivors: A Childhood Cancer Survivor Study and St Jude Lifetime Cohort Study Report.

Cindy Im Noha Sharafeldin Menglu Che Zhaoming Wang Yadav Sapkota Zhanni Lu Logan G SpectorRebecca M HowellMichael A ArnoldMelissa M Hudson Kristen K Ness Leslie L Robison Smita BhatiaGregory T ArmstrongJoseph P Neglia Yutaka Yasui Lucie M Turcotte

Published in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2023)

A pleiotropic cancer PRS has strong potential for improving SMN clinical risk stratification among nonirradiated survivors treated with specific chemotherapies. A polygenic risk screening approach may be a valuable complement to an early screening strategy on the basis of treatments and rare cancer-susceptibility mutations.

Keyphrases

childhood cancer
young adults
papillary thyroid
squamous cell carcinoma
lymph node metastasis
risk assessment
drug induced