Improved Risk Stratification in Pediatric Septic Shock Using Both Protein and mRNA Biomarkers. PERSEVERE-XP.

Hector R WongNatalie Z CvijanovichNick AnasGeoffrey L AllenNeal J ThomasMichael T BighamScott L WeissJulie C FitzgeraldPaul A ChecchiaKeith MeyerMichael QuasneyMark HallRainer GedeitRobert J FreishtatJeffrey NowakShekhar S RajShira GertzJocelyn R GrunwellChristopher J Lindsell

Published in: American journal of respiratory and critical care medicine (2017)

PERSEVERE-XP combines protein and mRNA biomarkers to provide mortality risk stratification with possible clinical utility. PERSEVERE-XP significantly improves on PERSEVERE and suggests a role for TP53-related cellular division, repair, and metabolism in the pathophysiology of septic shock.

Keyphrases

septic shock
binding protein
protein protein
amino acid
cardiovascular events
risk factors
coronary artery disease