Functional analysis of the secondary HIV-1 capsid binding site in the host protein cyclophilin A.

Wang PengJiong ShiChantal L MárquezDerrick LauJames WalshK M Rifat FaysalChang H ByeonIn-Ja L ByeonChristopher AikenTill Boecking

Published in: Retrovirology (2019)

The amino acid changes at A25, K27, P29 and K30 did not affect the affinity of CypA for the CA lattice and did not impair CypA function in infection assays suggesting that these residues are not part of a secondary CA binding site on CypA.

Keyphrases

amino acid
antiretroviral therapy
hiv positive
hiv infected
human immunodeficiency virus
hiv testing
hepatitis c virus
hiv aids
men who have sex with men
protein protein
small molecule
mass spectrometry
capillary electrophoresis
south africa