Serial MRI studies over 12 months using manual and atlas-based region of interest in patients with amyotrophic lateral sclerosis.
Ashwag Rafea AlruwailiKerstin PannekRobert D HendersonMarcus GrayNyoman D KurniawanPamela A McCombePublished in: BMC medical imaging (2020)
While previous DTI studies showed significant differences between ALS subjects and controls, within individual subjects there is little evidence of progression over 12 months. This suggests that DTI is not a suitable biomarker to assess disease progression in ALS.