Central nervous system (CNS) involvement has an adverse impact on survival in newly diagnosed adult acute lymphoblastic leukemia (ALL) assessed by flow cytometry.
Rosana Daniela Córdova-SerranoEmmanuel Almanza-HuanteEmmanuel Fernández-SánchezAreli Hernández-AlcántaraKarla Espinosa-BautistaPublished in: Leukemia & lymphoma (2021)
The role of CNS involvement detected by flow cytometry (FCM) in patients with acute lymphoblastic leukemia has been discussed previously; however, its impact on survival has not been described enough. We analyzed a retrospective cohort of newly diagnosed ALL adult patients who had a cerebrospinal fluid (CSF) analysis by FCM and conventional cytology. We evaluated 81 patients; 19 (23.4%) were only positive by FCM, five (6.3%) were double-positive (DP) and 57 (70.4%) were double-negative (DN). The detection of CNS involvement was increased from 6% to 24%, employing FCM; In our final analysis, patients with FCM + had a lower survival of 7.01 months [95% CI (5.90-8.24)], compared with 11.71 months [IC95% (9.49-13.94)] in the DN group (p = 0.03).
Keyphrases
- newly diagnosed
- flow cytometry
- acute lymphoblastic leukemia
- cerebrospinal fluid
- blood brain barrier
- allogeneic hematopoietic stem cell transplantation
- end stage renal disease
- ejection fraction
- high grade
- emergency department
- young adults
- prognostic factors
- electronic health record
- childhood cancer
- quantum dots
- real time pcr