Tissue-Specific Metabolic Regulation of FOXO-Binding Protein: FOXO Does Not Act Alone.
Noriko KodaniJun NakaePublished in: Cells (2020)
The transcription factor forkhead box (FOXO) controls important biological responses, including proliferation, apoptosis, differentiation, metabolism, and oxidative stress resistance. The transcriptional activity of FOXO is tightly regulated in a variety of cellular processes. FOXO can convert the external stimuli of insulin, growth factors, nutrients, cytokines, and oxidative stress into cell-specific biological responses by regulating the transcriptional activity of target genes. However, how a single transcription factor regulates a large set of target genes in various tissues in response to a variety of external stimuli remains to be clarified. Evidence indicates that FOXO-binding proteins synergistically function to achieve tightly controlled processes. Here, we review the elaborate mechanism of FOXO-binding proteins, focusing on adipogenesis, glucose homeostasis, and other metabolic regulations in order to deepen our understanding and to identify a novel therapeutic target for the prevention and treatment of metabolic disorders.
Keyphrases
- transcription factor
- oxidative stress
- genome wide identification
- dna binding
- signaling pathway
- binding protein
- genome wide
- gene expression
- dna damage
- ischemia reperfusion injury
- induced apoptosis
- dna methylation
- heavy metals
- diabetic rats
- cell proliferation
- endoplasmic reticulum stress
- cell therapy
- risk assessment
- blood glucose