Synergetic effects and inhibition mechanisms of the polysaccharide-selenium nanoparticle complex on human hepatocarcinoma cells proliferation.

FLDP-SeNPs could exert a synergetic toxicity reduction and inhibition enhancement effect on HepG2 cells via inducement of early apoptosis, through a mitochondria-mediated cytochrome C-Caspases and ROS-induced DNA damage pathways. These results manifest that FLDP-SeNPs treatment of HepG2 cells induced early apoptosis with synergetic efficacy, making FLDP-SeNPs useful as natural anti-tumor agents. This article is protected by copyright. All rights reserved.