The transient receptor potential A1 ion channel (TRPA1) modifies in vivo autonomous ureter peristalsis in rats.

Philipp WeinholdLuca VillaFrank StrittmatterChristian GratzkeChristian G StiefFabio CastiglioneFrancesco MontorsiPetter Hedlund

Published in: Neurourology and urodynamics (2020)

In rats, TRPA1 is expressed on cellular structures considered of importance for peristaltic and mechanoafferent functions of the ureter. Functional data indicate that TRPA1-mediated signals regulate ureter peristalsis. This effect was pronounced after mucosal disruption and suggests a role for TRPA1 in ureter pathologies involving urothelial damage.

Keyphrases

urinary tract
oxidative stress
electronic health record
high grade
risk assessment
ulcerative colitis
cerebral ischemia
human health
subarachnoid hemorrhage