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Regulation of Ptbp1-controlled alternative splicing of pyruvate kinase muscle by Liver kinase b1 governs vascular smooth muscle cell plasticity in vivo.

Zhaohua CaiGanesh SatyanarayanaPing SongFujie ZhaoShaojin YouZhixue LiuJing MuYe DingBen HeMing-Hui Zou
Published in: Cardiovascular research (2024)
Lkb1, via its regulation of Ptbp1-dependent alterative splicing of PKM, maintains VSMC in contractile states by suppressing VSMC plasticity.
Keyphrases
  • smooth muscle
  • skeletal muscle
  • protein kinase
  • single cell
  • tyrosine kinase
  • stem cells
  • mesenchymal stem cells