Elucidating the glucose-lowering effect of the bile acid sequestrant sevelamer.

Henriette H NerildAndreas BrøndenAbdullah E HaddouchiAnne-Marie EllegaardBolette HartmannJens F RehfeldJens J HolstDavid P SonneTina VilsbøllFilip K Krag Knop

Published in: Diabetes, obesity & metabolism (2023)

we were not able to detect a GLP-1-mediated glucose-lowering effect of sevelamer in individuals with type 2 diabetes. Nevertheless, the sevelamer-induced improvement of beta-cell sensitivity to glucose was shown to be GLP-1-dependent.

Keyphrases

blood glucose
high glucose
cell therapy
metabolic syndrome
blood pressure
adipose tissue
endothelial cells
oxidative stress
mesenchymal stem cells
drug induced
insulin resistance