Antifungal activity of β-lapachone against azole-resistant Candida spp. and its aspects upon biofilm formation.
Cecília Rocha da SilvaRosana de S CamposJoão B de A NetoLetícia S SampaioFrancisca Bsa do NascimentoLívia G do Av SáThiago M CândidoHemerson If MagalhãesEduardo Hg da CruzEufrânio N da Silva JúniorManoel O de MoraesBruno C CavalcantiJacilene SilvaEmmanuel S MarinhoHélio Vn JúniorPublished in: Future microbiology (2020)
Aim: The purpose of this study was to assess the antifungal effect of β-lapachone (β-lap) on azole-resistant strains of Candida spp. in both planktonic and biofilm form. Materials & methods: The antifungal activity of β-lap was evaluated by broth microdilution, flow cytometry and the comet assay. The cell viability of the biofilms was assessed using the MTT assay. Results: β-lap showed antifungal activity against resistant strains of Candida spp. in planktonic form. In addition, β-lap decreased the viability of mature biofilms and inhibited the formation of biofilms in vitro. Conclusion: β-lap showed antifungal activity against Candida spp., suggesting that the compound can be utilized as an adjunct agent in the treatment of candidiasis.