High-frequency oscillations are not better biomarkers of epileptogenic tissues than spikes.

Nicolas RoehriFrancesca PizzoStanislas LagardeIsabelle LambertAnca NicaAileen McGonigalBernard GiusianoFabrice BartolomeiChristian-George Bénar

Published in: Annals of neurology (2019)

At the patient level, the performance of HFOs is weakened by the presence of strong physiological HFO generators. Fast ripples are not sensitive enough to be the unique biomarker of epileptogenicity. Nevertheless, combining HFOs and spikes using our proposed measure-the cross-rate-is a better strategy than using only one marker. Ann Neurol 2018;83:84-97.

Keyphrases

high frequency
transcranial magnetic stimulation
case report
gene expression
working memory
neural network