Transcriptome analysis defines myocardium gene signatures in children with ToF and ASD and reveals disease-specific molecular reprogramming in response to surgery with cardiopulmonary bypass.
Federica RaggiDavide CangelosiPamela BecheriniFabiola BlengioMartina MoriniMassimo AcquavivaMaria Luisa BelliGiuseppe PanizzonGiuseppe CervoLuigi VaresioAlessandra EvaMaria Carla BoscoPublished in: Journal of translational medicine (2020)
Our results provide a comprehensive view of gene reprogramming in right atrium tissues of ToF and ASD patients before and after CPB, defining specific molecular pathways underlying disease pathophysiology and myocardium response to CPB. These findings have potential translational value because they identify new candidate prognostic markers and targets for tailored cardioprotective post-surgical therapies.
Keyphrases
- autism spectrum disorder
- mass spectrometry
- genome wide
- ms ms
- end stage renal disease
- newly diagnosed
- copy number
- ejection fraction
- attention deficit hyperactivity disorder
- minimally invasive
- young adults
- intellectual disability
- gene expression
- coronary artery bypass
- coronary artery disease
- pulmonary artery
- inferior vena cava
- pulmonary hypertension
- human health
- acute coronary syndrome
- percutaneous coronary intervention