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Inhibition of Notch4 Using Novel Neutralizing Antibodies Reduces Tumor Growth in Murine Cancer Models by Targeting the Tumor Endothelium.

Jason W-L EngYu KatoYusuke AdachiBhairavi SwaminathanL A NaicheRahul VadakathYoshimasa SakamotoYouya NakazawaSho TachinoKen ItoTakanori AbeYukinori MinoshimaKana Hoshino-NegishiHideaki OgasawaraTomomi KawakatsuMiyuki NishimuraMasahiko KatayamaMasashi ShimizuKazuhiro TaharaToshitaka SatoKatsuhisa SuzukiKishan AgarwalaMasao IwataKenichi NomotoYoichi OzawaToshio ImaiYasuhiro FunahashiJunji MatsuiJan K Kitajewski
Published in: Cancer research communications (2024)
A first-in-class anti-Notch4 agent, E7011, demonstrates strong antitumor effects in murine tumor models including breast carcinoma. Endothelial Notch4 blockade reduces perfusion and vessel area.
Keyphrases
  • cell proliferation
  • papillary thyroid
  • nitric oxide
  • endothelial cells
  • magnetic resonance imaging
  • squamous cell
  • squamous cell carcinoma
  • dengue virus
  • contrast enhanced
  • zika virus