Inhibition of Notch4 Using Novel Neutralizing Antibodies Reduces Tumor Growth in Murine Cancer Models by Targeting the Tumor Endothelium.
Jason W-L EngYu KatoYusuke AdachiBhairavi SwaminathanL A NaicheRahul VadakathYoshimasa SakamotoYouya NakazawaSho TachinoKen ItoTakanori AbeYukinori MinoshimaKana Hoshino-NegishiHideaki OgasawaraTomomi KawakatsuMiyuki NishimuraMasahiko KatayamaMasashi ShimizuKazuhiro TaharaToshitaka SatoKatsuhisa SuzukiKishan AgarwalaMasao IwataKenichi NomotoYoichi OzawaToshio ImaiYasuhiro FunahashiJunji MatsuiJan K KitajewskiPublished in: Cancer research communications (2024)
A first-in-class anti-Notch4 agent, E7011, demonstrates strong antitumor effects in murine tumor models including breast carcinoma. Endothelial Notch4 blockade reduces perfusion and vessel area.