Armochaetoglasins L and M, new cytochalasans from an arthropod-derived fungus Chaetomium globosum .

Armochaetoglasins L ( 1 ) and M ( 2 ), two new cytochalasans, were isolated from the EtOAc extract of an arthropod-derived fungus Chaetomium globosum . Armochaetoglasin L ( 1 ) is a rare 19,20- seco -chaetoglobosin. Their structures were elucidated by NMR spectroscopy and comparison of their electronic circular dichroism (ECD) data. Compounds 1 and 2 were evaluated for anti-inflammatory activity against the NO production by using LPS-stimulated murine macrophage RAW264.7 cells and antibacterial activity against three drug-resistant microbial pathogens.