Extended Conjugation Tuning Carbon Nitride for Non-sacrificial H<sub>2</sub> O<sub>2</sub> Photosynthesis and Hypoxic Tumor Therapy.
Jin MaXiaoxiao PengZhixin ZhouHong YangKaiqing WuZhengzou FangDan HanYanfeng FangSongqin LiuYanfei ShenFrank C J M van VeggelPublished in: Angewandte Chemie (International ed. in English) (2022)
Artificial photocatalysis offers a clean approach for producing H<sub>2</sub> O<sub>2</sub> . However, the poor selectivity and activity of H<sub>2</sub> O<sub>2</sub> production hamper traditional industrial applications and emerging photodynamic therapy (PDT)/chemodynamic therapy (CDT). Herein, we report a C<sub>5</sub> N<sub>2</sub> photocatalyst with a conjugated C=N linkage for selective and efficient non-sacrificial H<sub>2</sub> O<sub>2</sub> production in both normoxic and hypoxic systems. The strengthened delocalization of π-electrons by linkers in C<sub>5</sub> N<sub>2</sub> downshifted the band position, thermodynamically eliminating side H<sub>2</sub> evolution reaction and kinetically promoting water oxidation. As a result, C<sub>5</sub> N<sub>2</sub> had a competitive solar-to-chemical conversion efficiency of 0.55 % in overall H<sub>2</sub> O<sub>2</sub> production and exhibited by far the highest activity under hypoxic conditions (698 μM h<sup>-1</sup> ). C<sub>5</sub> N<sub>2</sub> was further applied to hypoxic PDT/CDT with outstanding performance in apparent cancer cell death and synchronous bioimaging. The study sheds light on the photosynthesis of H<sub>2</sub> O<sub>2</sub> by carbon nitrides for health applications.
Keyphrases
- photodynamic therapy
- visible light
- cell death
- fluorescence imaging
- healthcare
- public health
- quantum dots
- mental health
- wastewater treatment
- genome wide
- heavy metals
- gene expression
- nitric oxide
- mesenchymal stem cells
- computed tomography
- hepatitis c virus
- health information
- cell cycle arrest
- young adults
- cell therapy
- men who have sex with men
- fluorescent probe
- reduced graphene oxide
- single molecule
- diffusion weighted imaging
- replacement therapy
- pi k akt
- health promotion