Association of age with response to preoperative chemotherapy in patients with muscle-invasive bladder cancer.
David D'AndreaPeter C BlackHomayoun ZargarKamran Zargar-ShoshtariFrancesco SoriaAdrian S FaireyLaura S MertensColin P DinneyMaria C MirLaura-Maria KrabbeMichael S CooksonNiels-Erik JacobsenJeffrey S MontgomeryNikhil VasdevEvan Y YuEvanguelos XylinasNicholas J CampainWassim KassoufMarc A Dall'EraJo-An SeahCesar E ErcoleSimon HorenblasSrikala S SridharJohn S McGrathJonathan AningJonathan L WrightAndrew C ThorpeTodd M MorganJeff M HolzbeierleinTrinity J BivalacquaScott NorthDaniel A BarocasYair LotanPetros GrivasAndrew J StephensonJay B ShahBas W van RhijnSiamak DaneshmandPhilippe E SpiessShahrokh F ShariatPublished in: World journal of urology (2021)
While younger patients may have less mutational tumor burden, our analysis failed to show an association of age with response to preoperative chemotherapy or survival outcomes. Therefore, the use of preoperative chemotherapy should be considered regardless of patient age.