Translational engagement of lysophosphatidic acid receptor 1 in skin fibrosis: from dermal fibroblasts of patients with scleroderma to tight skin 1 mouse.

Laetitia LedeinBertrand LégerClara Dees Christian BeyerAlfiya DistlerSerena VettoriRachid BoukaibaJean-Pierre BidouardMatthias SchaeferJosef PernerstorferHartmut RuettenAlexandre JagerschmidtPhilip Janiak Jörg H W Distler Oliver Distler Stephane Illiano

Published in: British journal of pharmacology (2020)

The effects of SAR100842 on LPA-induced inflammation and on mechanisms linked to fibrosis like myofibroblast differentiation and Wnt pathway activation indicate that LPA1 receptor activation plays a key role in skin fibrosis. Our results support the therapeutic potential of LPA1 receptor antagonists in systemic sclerosis.

Keyphrases

systemic sclerosis
interstitial lung disease
wound healing
soft tissue
stem cells
liver fibrosis
blood brain barrier
social media
cell proliferation
high glucose
transforming growth factor
binding protein
extracellular matrix
idiopathic pulmonary fibrosis
endothelial cells
epithelial mesenchymal transition