Anti-C1q autoantibodies from systemic lupus erythematosus patients enhance CD40-CD154-mediated inflammation in peripheral blood mononuclear cells in vitro .

Pascal Alexander Rabatscher Marten Trendelenburg

Published in: Clinical & translational immunology (2022)

In conclusion, C1q/anti-C1q have a pro-inflammatory effect on monocytes that depends on T cell activation and CD40-CD154 signalling. This signalling pathway could serve as a therapeutic target for anti-C1q-mediated inflammation.

Keyphrases

systemic lupus erythematosus
end stage renal disease
oxidative stress
newly diagnosed
ejection fraction
chronic kidney disease
peritoneal dialysis
prognostic factors
dendritic cells