Development of a 3D functional assay and identification of biomarkers, predictive for response of high-grade serous ovarian cancer (HGSOC) patients to poly-ADP ribose polymerase inhibitors (PARPis): targeted therapy.

Razan ShetaMagdalena BachvarovaMarie PlanteMarie-Claude RenaudAlexandra SebastianelliJean GregoireJamilet Miranda NavarroRicardo Bringas PerezJean-Yves MassonDimcho Bachvarov

Published in: Journal of translational medicine (2020)

The application of this assay and the potential biomarkers with possible predictive significance to PARPis therapy of EOC patients now need testing in the setting of a clinical trial.

Keyphrases

high grade
end stage renal disease
clinical trial
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
high throughput
prognostic factors
low grade
patient reported outcomes
bone marrow
double blind
cell therapy
structural basis