Topoisomerase I Inhibition Radiosensitizing Hepatocellular Carcinoma by RNF144A-mediated DNA-PKcs Ubiquitination and Natural Killer Cell Cytotoxicity.

Chiao-Ling Tsai Po-Sheng Yang Feng-Ming Hsu Ann-Lii ChengWan-Ni YuJason Chia-Hsien Cheng

Published in: Journal of clinical and translational hepatology (2023)

TOP1i reinforces NK cell-activated anti-HCC effect of RT through RNF144A mediated DNA-PKcs ubiquitination. RNF144A provides a reason for differentiating radiosensitization effect between HCC cells.

Keyphrases

nk cells
circulating tumor
cell free
induced apoptosis
dna damage response
single molecule
single cell
cell cycle arrest
cell therapy
computed tomography
cell proliferation
oxidative stress
magnetic resonance
stem cells
dna damage
bone marrow