Topical noninvasive retinal drug delivery of a tyrosine kinase inhibitor: 3% cediranib maleate cyclodextrin nanoparticle eye drops in the rabbit eye.

Laura Lorenzo-SolerPitsiree PraphanwittayaOlof Birna OlafsdottirIris Myrdal KristinsdottirGudrun Marta AsgrimsdottirThorsteinn LoftssonEinar Stefánsson

Published in: Acta ophthalmologica (2022)

value reported for the VEGF type-II receptor and thus, presumably, above therapeutic level. These results suggest that γ-cyclodextrin-based cediranib maleate eye drops deliver effective drug concentrations to the retina in rabbits after a single-dose administration.

Keyphrases

drug delivery
diabetic retinopathy
optic nerve
optical coherence tomography
ionic liquid
endothelial cells
capillary electrophoresis
emergency department
cancer therapy
adverse drug
binding protein