Interference of bovine hemoglobin-based oxygen carrier-201 (Hemopure) on four hematology analyzers.

Marinke W Bronkhorst-van der HelmFloor WeerkampAlbert HuismanElise J HuismanHenk Russcher

Published in: International journal of laboratory hematology (2023)

Of all included hematology parameters, only total Hb and the associated MCH and MCHC suffered from interference. In contrast, the flow cytometry-based Hb measurement provided an accurate measure of intracellular Hb. The difference between total Hb and cellular Hb represents the HBOC-201 concentration and can be used to monitor HBOC-201 treatment.

Keyphrases

flow cytometry
magnetic resonance
high resolution
magnetic resonance imaging
computed tomography
replacement therapy