Genetic Markers of Insulin Resistance and Atherosclerosis in Type 2 Diabetes Mellitus Patients with Coronary Artery Disease.
Sangeetha PerumalsamyHasniza Zaman HuriBashar Mudhaffar AbdullahOthman MazlanWan Azman Wan AhmadShireene Ratna D B VethakkanPublished in: Metabolites (2023)
Type 2 diabetes mellitus (T2DM) is characterized by impaired insulin secretion on a background of insulin resistance (IR). IR and T2DM are associated with atherosclerotic coronary artery disease (CAD). The mechanisms of IR and atherosclerosis are known to share similar genetic and environmental roots. Endothelial dysfunction (ED) detected at the earliest stages of IR might be the origin of atherosclerosis progression. ED influences the secretion of pro-inflammatory cytokines and their encoding genes. The genes and their single nucleotide polymorphisms (SNPs) act as potential genetic markers of IR and atherosclerosis. This review focuses on the link between IR, T2DM, atherosclerosis, CAD, and the potential genetic markers CHI3L1 , CD36 , LEPR , RETN , IL-18 , RBP-4 , and RARRES2 genes.
Keyphrases
- genome wide
- coronary artery disease
- insulin resistance
- cardiovascular disease
- dna methylation
- copy number
- glycemic control
- emergency department
- metabolic syndrome
- type diabetes
- human health
- percutaneous coronary intervention
- polycystic ovary syndrome
- coronary artery bypass grafting
- gene expression
- bioinformatics analysis
- acute coronary syndrome
- risk assessment
- cardiovascular events
- weight loss
- genome wide analysis
- anti inflammatory