Serine, N-acetylaspartate differentiate adolescents with juvenile idiopathic arthritis compared with healthy controls: a metabolomics cross-sectional study.
Kimberly A LewisNico OsierRuy CarrascoJennifer ChiouPatricia CarterAlexandra GarciaElena FlowersEfstathios D GennatasChristina NguyenAmbreen RanaSharon A BrownStefano TizianiPublished in: Pediatric rheumatology online journal (2022)
The metabolic signature of adolescents with JIA relative to controls reflects a disruption in oxidative stress; neurological health; and amino acid, caffeine, and energy metabolism pathways. Serine and N-acetylaspartate were promising potential biomarkers, and their metabolic pathways are linked to both JIA and cardiovascular disease risk. The pathways may be a source of new diagnostic, treatment, or prevention options. This study's findings contribute new knowledge for systems biology and precision health approaches to JIA research. Further research is warranted to confirm these findings in a larger sample.
Keyphrases
- juvenile idiopathic arthritis
- healthcare
- cardiovascular disease
- young adults
- oxidative stress
- public health
- disease activity
- amino acid
- physical activity
- mental health
- health information
- mass spectrometry
- type diabetes
- protein kinase
- health promotion
- dna damage
- rheumatoid arthritis
- metabolic syndrome
- human health
- systemic lupus erythematosus
- ischemia reperfusion injury
- risk assessment
- coronary artery disease
- induced apoptosis
- cardiovascular risk factors
- climate change
- cardiovascular events
- heat stress