Aberrant translation regulated by METTL1/WDR4-mediated tRNA N7-methylguanosine modification drives head and neck squamous cell carcinoma progression.

Jie ChenKang LiJianwen ChenXiaochen WangRongsong LingMaosheng ChengZhi ChenFangfang ChenQianting HeShuai LiCaihua ZhangYizhou JiangQianming ChenAnxun WangDemeng Chen

Published in: Cancer communications (London, England) (2022)

G methyltransferase METTL1 was found to promote the development and malignancy of HNSCC through regulating global mRNA translation, including the PI3K/AKT/mTOR signaling pathway, and found to alter immune landscape. METTL1 could be a promising treatment target for HNSCC patients.

Keyphrases

end stage renal disease
signaling pathway
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
pi k akt
single cell