Possible link between familial susceptibility to cancer and the level of oxidative stress in thyroid cancer patients.
Ivane JavakhishviliKote MardaleishviliMaka BuleishviliMaia MantskavaIrakli ChkhikvishviliSophio KalmakhelidzeNina KipianiTamar SanikidzePublished in: Hereditary cancer in clinical practice (2024)
=0.15), CONCLUSIONS: Oxidative stress plays a critical role in tumorigenesis, and antioxidant/oxidant imbalance may contribute to the malignant transformation of normal tissue. In patients with familial susceptibility to cancer mutations of several genes, which are involved in the regulation of oxidative metabolism, may contribute to the disruption of the redox balance, increase the level of oxidative stress, and contribute to the development of thyroid cancer.
Keyphrases
- oxidative stress
- papillary thyroid
- end stage renal disease
- dna damage
- diabetic rats
- ischemia reperfusion injury
- squamous cell
- induced apoptosis
- newly diagnosed
- ejection fraction
- early onset
- chronic kidney disease
- peritoneal dialysis
- anti inflammatory
- lymph node metastasis
- childhood cancer
- dna methylation
- genome wide identification
- signaling pathway