Role of heme in lung bacterial infection after trauma hemorrhage and stored red blood cell transfusion: A preclinical experimental study.
Andrew B BarkerParker J HuJoo-Yeun OhCilina A EvansJillian R RichterJaideep HonavarAngela P BrandonJudy CreightonShannon W StephensCharity MorganRandal O DullMarisa B MarquesJeffrey David KerbyJean-Francois PittetRakesh P PatelPublished in: PLoS medicine (2018)
We provide evidence that large volume resuscitation with stored blood, compared to fresh blood, in mice increases mortality from subsequent pneumonia, which occurs via mechanisms sensitive to hemopexin and TLR4 and HMGB1 inhibition.
Keyphrases