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An updated patent review on monoamine oxidase (MAO) inhibitors.

Paolo GuglielmiSimone CarradoriIlaria D'AgostinoCristina CampestreJacobus P Petzer
Published in: Expert opinion on therapeutic patents (2022)
MAO inhibitors here reported exhibit different potencies and isoform selectivity. These compounds are clinically licensed for multi-faceted neurodegenerative pathologies due to their ability to also act against other relevant targets (cholinesterases, inflammation, and oxidative stress). Moreover, the drug repurposing approach is an attractive strategy by which MAO inhibitors may be applied for the treatment of prostate cancer, inflammation, vertigo, and type 1 diabetes.
Keyphrases
  • oxidative stress
  • prostate cancer
  • type diabetes
  • dna damage
  • diabetic rats
  • cardiovascular disease
  • ischemia reperfusion injury
  • insulin resistance
  • emergency department
  • combination therapy
  • skeletal muscle
  • heat shock