Evidence that phospholipase C is involved in the antitumour action of NSC768313, a new thieno[2,3-b]pyridine derivative.
Jóhannes ReynissonJagdish K JaiswalDavid BarkerStacey A N D'melloWilliam A DennyBruce C BaguleyEuphemia Y LeungPublished in: Cancer cell international (2016)
The results are consistent with a mechanism in which thieno[2,3-b]pyridine derivatives interact with PLC isoforms (possibly PLC-δ), which in turn affect the cellular dynamics of tubulin-β, inducing cell cycle arrest in G2-phase. We conclude that these compounds have novelty because of their PLC target and may have utility in combination with mitotic poisons for cancer treatment.