Excessive cleavage of von Willebrand factor multimers by ADAMTS13 may predict the progression of transplant-associated thrombotic microangiopathy.
Shinya YamadaKazuya SakaiMasayuki KuboHirokazu OkumuraHidesaku AsakuraToshihiro MiyamotoMasanori MatsumotoPublished in: Research and practice in thrombosis and haemostasis (2024)
During the transition from probable to definite TMA, drastic VWF multimer changes imply a switch from bleeding to thrombotic tendencies. Extensive VWF-DP and VWF multimer analyses provided novel insights.