α-Synuclein Seed Amplification Assays in the Diagnosis of Synucleinopathies Using Cerebrospinal Fluid-A Systematic Review and Meta-Analysis.

Anna GrossauerGreta HemickerFlorian Krismer Marina PeballAtbin DjamshidianWerner PoeweKlaus Seppi Beatrice Heim

Published in: Movement disorders clinical practice (2023)

While our study clearly demonstrated a high diagnostic performance of RT-QuIC and PMCA for differentiating synucleinopathies with Lewy bodies from controls, results for the diagnosis of multiple system atrophy were less robust.

Keyphrases

cerebrospinal fluid
parkinson disease
high throughput
magnetic resonance imaging
computed tomography
single cell
label free