Virus-derived gene transfer agents benefit host cells by providing templates for DNA repair.

Published in: PLoS biology (2022)

The potential benefits of producing gene transfer agents (GTAs) have long been speculated. A new study in PLOS Biology shows that DNA transfer by these phage-like elements allows cells with DNA damage to perform DNA repair and survive.

Keyphrases

dna repair
dna damage
induced apoptosis
dna damage response
oxidative stress
copy number
genome wide
endoplasmic reticulum stress
circulating tumor
cystic fibrosis
nucleic acid
genome wide analysis